Uteroglobin, aka Club cell (formerly Clara cell) protein (CC16) is a member of the secretoglobin family of small disulphide bridge dimeric proteins. Its name is derived from its very high expression in the preimplantation uterus. It is secreted by non-ciliated epithelial non-mucous secretory cells that predominate in lung bronchioles (Club cells) and other non-ciliated epithelia. It is the most abundant protein present in normal airway secretions. Uteroglobin participates in several immunoregulatory activities, including sequestering prostaglandins and leukotrienes. Low plasma uteroglobin are seen with asthma, COPD and cigarette smoking. Conversely, disruption of the lung epithelial barrier function by acute injury may cause an increase circulating uteroglobin. Serum CC16 levels have be shown to be inversely associated with mortality risk.
Swiss-Prot Accession Number: P11684