Aggrecan core protein (Aggrecan)

Aggrecan is a high molecular weight proteoglycan. It exhibits a bottlebrush structure, in which chondroitin sulfate and keratan sulfate chains are attached to an extended protein core. It is one of the of the major ECM components of cartilage and provides the ability to resist compressive forces. Aggrecan fills the interstices of the collagen meshwork by forming large aggregated complexes interacting with hyaluronan and link proteins. Aggrecan is produced by chondrocytes, and its production is regulated by cytokines and growth factors such as IL1ß, TNFa, IGF1 or TGFß. Aggrecan fragments detected in serum may be indicative of cartilage deterioration during joint injury, arthritis, and aging.

Swiss-Prot Accession Number: P16112