Dopamine beta-hydroxylase (DBH)
Dopamine b-hydroxylase is a a copper-containing enzyme that converts dopamine into norepinepherine/adrenaline. It has both soluble and membrane-bound forms where the un-cleaved 25aa signal sequence serves as the membrane anchor. It is expressed in neurons and adrenal medullary cells. Decreased levels of DBH are associated with parkinsonâ€™s disease, whereas increased expression is linked to schizophrenia, depression, hypertension, and stress. Circulating DBH levels are also increased in an experimentally-induced rat model of diabetes.
Swiss-Prot Accession Number: P09172