Dopamine beta-hydroxylase (DBH)
Dopamine b-hydroxylase is a a copper-containing enzyme that converts dopamine into norepinepherine/adrenaline. It has both soluble and membrane-bound forms where the un-cleaved 25aa signal sequence serves as the membrane anchor. It is expressed in neurons and adrenal medullary cells. Decreased levels of DBH are associated with parkinson’s disease, whereas increased expression is linked to schizophrenia, depression, hypertension, and stress. Circulating DBH levels are also increased in an experimentally-induced rat model of diabetes.
Swiss-Prot Accession Number: P09172