Ficolin-3

Ficolins are a group of proteins containing both a collagen-like domain and a fibrinogen-like domain. Three forms of ficolin have been identified in humans. Ficolin- 3 is synthesized both in the liver and in the lung. Ficolin-2 forms a complex with MASP-2 and microbial surfaces and activates the C3 convertase C4bC2b, which leads to opsonizatio and lysis of pathogens and recruitment of inflammatory cells.Low ficolin-3 serum levels have been associated with the severity and unfavorable outcome of acute ischemic stroke, insulin resistance and bacteraemia during chemotherapy.

Swiss-Prot Accession Number: O75636


Myriad RBM Publications Publications
Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome (2018) Lal C, Hardiman G, Kumbhare S, Strange C Sleep and Breathing
Type I interferon receptor blockade with anifrolumab corrects innate and adaptive immune perturbations of SLE (2018) Casey KA, Guo X, Smith MA, Wang S, Sinibaldi D, Sanjuan MA, Wang L, Illei GG, White WI Lupus Science and Medicine