Visceral adipose tissue - derived serpin A12 (Vaspin)

Vaspin, an insulin-sensitizing adipokine, is a secreted member of the a1-antitrypsin (clade A) subfamily of the Serpin superfamily of protease inhibitors. It is produced by visceral adipocytes and adipocyte-derived stem cells in obesity and diabetes. Recent studies indicate Vaspin may be associated with parameters of obesity, diabetes and insulin resistance and glucose metabolism. In insulin resistance, diabetes, as well as atherosclerosis inflammatory processes are involved and Vaspin might be a link between the endocrine and immune system. Oral contraceptives increase Vaspin serum levels

Swiss-Prot Accession Number: Q8IW75