Hemopexin

Hemopexin is a liver expressed acute phase reactant that binds and neutralizes prooxidant free heme, binding heme with the highest affinity of any known protein. In addition to being expressed in the liver, hemopexin is also seen in the central and peripheral nervous system and in the retina. Increased hemopexin levels have been associated with iron-related neurodegenerative diseases, cirrhosis and liver cancer. Decreased levels are a sign of anemia.

Swiss-Prot Accession Number: P02790


Publications
Feasibility of investigating differential proteomic expression in depression: implications for biomarker development in mood disorders (2015) Frye MA, Nassan M, Jenkins GD, Kung S, Veldic M, Palmer BA, Feeder SE, Tye SJ, Choi DS and Biernacka HM Translational Psychiatry