Osteocalcin is synthesized by osteoblasts and is found exclusively in bone tissue. During bone formation, newly synthesized osteocalcin is incorporated into the extracellular bone matrix and a small fraction is released into circulation and reflects bone formation activity. Serum osteocalcin is elevated in diseases characterized by increased bone turnover such as postmenopausal osteoporosis, Pagetâ€™s disease of the bone and hyperthyroidism. Serum osteocalcin levels have been found to be an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes as well as an indicator of bone metastasis in cancer.
Swiss-Prot Accession Number: P02818