Chemerin, also known as the Retinoic acid receptor responder protein 2, is a novel chemoattractant protein secreted as an 18-kDa inactive pro-protein. Active chemerin is abundant in ascetic fluid from ovarian cancer patients and synovial fluid from patients with arthritis. Signaling by chemerin is mediated by the seven-transmembrane-spanning G protein-coupled receptor, chemokine like receptor-1 (CMKLR1), ChemR23, or chemerinR. Both chemerin and chemerinR mRNA expression dramatically increases during the differentiation of preadipocytes into adipocytes.
Swiss-Prot Accession Number: Q99969