Interleukin-18-binding protein (IL-18bp)

Interleukin-18-binding protein (IL-18bp) is a secreted glycoprotein which functions as an antagonist to IL-18. It does this by binding to IL-18 and blocking it from binding to its receptors. IL-18bp shares no homology with the membrane bound IL-18 receptor. IL-18bp isoforms A and C contain a complete Ig domain, while isoforms B and D do not. This domain has been found to be necessary for proper binding function and maintaining its antagonistic characteristics. Expression of IL-18bp is known to be upregulated in patients with Crohn’s Disease, and by the presence of IFN-gamma.

Swiss-Prot Accession Number: O95998

Myriad RBM Publications Publications
Circulating Biomarkers and Outcome from a Randomised Phase Ii Trial of Sunitinib Vs Everolimus for Patients with Metastatic Renal Cell Carcinoma (2016) Voss MH, Chen D, Marker M, Hakimi AA, Lee C-H, Hsieh JJ, Knox JJ, Voi M, Motzer RJ British Journal of Cancer