Interleukin-18-binding protein (IL-18bp)
Interleukin-18-binding protein (IL-18bp) is a secreted glycoprotein which functions as an antagonist to IL-18. It does this by binding to IL-18 and blocking it from binding to its receptors. IL-18bp shares no homology with the membrane bound IL-18 receptor. IL-18bp isoforms A and C contain a complete Ig domain, while isoforms B and D do not. This domain has been found to be necessary for proper binding function and maintaining its antagonistic characteristics. Expression of IL-18bp is known to be upregulated in patients with Crohn’s Disease, and by the presence of IFN-gamma.
Swiss-Prot Accession Number: O95998