Beta Amyloid 1-42 (AB-42)

Beta Amyloid, also known as Abeta, (Aß42) is a peptide of 36–43 amino acids that appears to be the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. The most common isoforms are AB-40 and AB-42; the shorter form is typically produced by cleavage that occurs in the endoplasmic reticulum, while the longer form is produced by cleavage in the trans-Golgi network. The AB-40 form is the more common of the two, but AB-42 is the more fibrillogenic and is thus associated with disease states.

Swiss-Prot Accession Number: P05067