Cadherin-1 (E-Cad) is a member of the cadherin superfamily. Cadherins are transmembrane proteins that play an important role in cell adhesion, ensuring the cells within the tissue are bound together maintaining their integrity. To function, cadherins are dependent on calcium ions. Studies have shown that reduction and/or loss of E-cad expression in carcinomas correlates positively with the potential of tumors for invasion and metastasis.
Swiss-Prot Accession Number: P12830
Publications Anemia and Adverse Outcomes in a Chronic Obstructive Pulmonary Disease Population with a High Burden of Comorbidities
(2018) Putcha N, Fawzy A, Paul GG, Lambert AA, Psoter KJ, Sidhaye VK, Woo J, Wells JM, Labaki WW, Doerschuk CM, Kanner RE, Han MK, Martinez C, Paulin LM, Martinez FJ, Wise RA, O'Neal WK, Barr RG, Hansei NN AnnalsATS
Cigarette smoke disrupts monolayer integrity by altering epithelial cell-cell adhesion and cortical tension.
(2017) Nishida K, Brune KA, Putcha N, Mandke P, O'Neal WK, Shade D, Srivastava V, Wang M, Lam H, An SS, Drummond MB, Hansel NN, Robinson DN, Sidhaye VK. Am J Physiol Lung Cell Mol Physiol
The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes
(2014) Carolan BJ, Hughes G, Morrow J, Hersh CP, O'Neal WK, Rennard S, Pillai SG, Belloni P, Cockayne DA, Comellas AP, Han M, Zemans RL, Kechris K, Bowler RP. Respiratory Research 2014 Oct 12;15(1):127. doi: 10.1186/s12931-014-0127-9.