Urokinase-type Plasminogen Activator (uPA)
Urokinase-type Plasminogen Activator (uPA) is a 52-kDa serine proteinase. Active uPA rapidly converts the inactive plasmin precursor, plasminogen, to enzymatically active plasmin, which is directly involved in extracellular matrix degradation as well as in the activation of other procollagenases and latent growth factors. It is expressed in the prostate gland and prostate cancers. uPA is available commercially under the name Abbokinase (Abbott) and is used clinically for therapy of thrombolytic disorders such as pulmonary embolism where it initiates fibrinolysis.
Swiss-Prot Accession Number: P00749