Maspin

Maspin (Serpin B5) is a non-inhibitory member of the serpin family that is downregulated in breast carcinoma but overexpressed in pancreatic carcinoma. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Swiss-Prot Accession Number: P36952


 
Therapy Indications