Fibulin-1C (Fib-1C) is an extracellular matrix protein overexpressed in epithelial ovarian and breast cancers. Alternative splicing of fibulin-1 precursor results in four transcript variants designated A-D, of which C and D are predominantly expressed. Serum levels for this protein are not known, but previous experiments at RBM, where total fibulin-1 was examined, showed that the levels were in the high ng/ml range. As fibulin-1C is more relevant in ovarian cancer, a screen was performed to look at serum fibulin-1C levels.
Swiss-Prot Accession Number: P23142