Interferon gamma Induced Protein 10, short (IP-10, short)
Interferon gamma Induced Protein 10 (IP-10; 10kDa interferon-gamma-induced protein; CXCL10) is induced in a variety of cells in response to IFN-gamma. IP-10 inhibits bone marrow colony formation and angiogenesis, stimulates NK and T cell migration, regulates T cell maturation and modulates adhesion molecule expression. IP-10 induction to be involved in many disorders including autoimmune diseases, kidney injury, cancer and importantly, infectious diseases such as hepatitis C. For hepatitis C patients, measurement of the short and long forms have been used to predict the response to therapy. IP-10 is cleaved by the enzyme dipeptidyl peptidase IV (DPP4), resulting in increased amounts of the truncated (short) form of the protein that exhibits lower biological activity.
Swiss-Prot Accession Number: P02778