Soluble Neuropilin-1 (sNRP-1; sCD304; sVEGF165R) is the soluble isoform of a 130 kDa transmembrane receptor involved in angiogenesis and the mediation of neuronal growth. sNRP-1 binds VEGF165 and appears to inhibit its binding to cells. It may also bind various members of the semaphorin family. Its expression has an adverse effect on blood vessel number and integrity. The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney, and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, and the kidney distal and proximal tubules.
Swiss-Prot Accession Number: O14786
Publications Biomarkers and overall survival in patients with advanced hepatocellular carcinoma treated with TGF-ßRI inhibitor galunisertib.
(2020) Giannelli G, Santoro A, Kelley RK, Gane E, Paradis V, Cleverly A, Smith C, Estrem ST, Man M, Wang S, Lahn MM, Raymond E, Benhadji KA, Faivre S PLoS One
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment
(2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Circulating Biomarkers and Outcome from a Randomised Phase Ii Trial of Sunitinib Vs Everolimus for Patients with Metastatic Renal Cell Carcinoma
(2016) Voss MH, Chen D, Marker M, Hakimi AA, Lee C-H, Hsieh JJ, Knox JJ, Voi M, Motzer RJ British Journal of Cancer
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests
(2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports
Neuropilin 1 (NRP1) may be prognostic and identify a subgroup of Patients with Metastatic Colorectal Cancer (mCRC) who Benefit from Tivozanib + mFOLFOX6 compared to Bevacizumab + mFOLFOX6
(2015) Benson A, Krivoshik A, Van Sant C, Needle M Annals of Oncology
Prognostic/predictive value of 207 serum factors in colorectal cancer treated with cediranib and/or chemotherapy
(2013) Spencer SK, Pommier AJ, Morgan SR, Barry ST, Robertson JD, Hoff PM, Jürgensmeier JM Br J Cancer. 2013 Oct 22