P-Selectin

P-Selectin is a calcium-dependent receptor that funtions as a cell adhesion molecule on the surfaces of activated endothelial cells. It binds to carbohydrates on neutrophils and monocytes. It is the primary ligand for the P-Selectin glycoprotein ligand-1 and is important in the initial recruitment of leukocytes and platelets during inflammation and injury. P-Selectin has been implicated in the metastasis of cancer by aiding the invasion of cancer cells into the blood.

Swiss-Prot Accession Number: P16109


Publications
PF-04447943, a Phosphodiesterase 9A Inhibitor, in Stable Sickle Cell Disease Patients: A Phase Ib Randomized, Placebo-Controlled Study (2018) Charnigo RJ, Beidler D, Rybin D, Pittman DD, Tan B, Howard J, Michelson AD, Frelinger AL II, Clark N Clinical and Translational Science
A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression (2015) Cho HS, Shin HM, Haberstock-Debic H, Xing Y, Owens TD, Funk JO, Hill RJ, Bradshaw JM, Berg LJ J Immunol.