Osteoprotegerin (OPG), also known as Tumor necrosis factor receptor superfamily member 11B, is a member of the tumor necrosis factor receptor superfamily that lacks any apparent cell association motifs and exists as a soluble secreted protein. OPG acts as a decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. OPG may act as decoy receptor for TRAIL and protect against apoptosis. Several studies have shown that serum markers of bone turnover may be able to determine the time-to-tumor progression, metastatic potential, and overall survival in cancer patients.
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