Angiopoietin-1 (ANG-1) plays a critical role in embryogenic angiogenesis and in maintaining the integrity of adult vasculature. Human ANG-1 has 97% homology with mouse ANG-1. It activates TIE-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. ANG-1 may also play a role in the early development of the heart.
Swiss-Prot Accession Number: Q15389
Publications A clinical and proteomics approach to predict the presense of obstructive peripheral arterial disease (From CASABLANCA)
(2018) McCarthy CP, Ibrahim NE, van Kimmenade RRJ, Gaggin HK, Simon ML, Gandhi P, Kelly N, Motiwala SR, Mukai R, Magaret CA, Barnes G, Rhyne RF, Garasic JM, Januzzi JL Jr Clin Cardiol
Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome
(2018) Lal C, Hardiman G, Kumbhare S, Strange C Sleep and Breathing
Association between Cytokines and Functional, Hemodynamic Parameters, and Clinical Outcomes in Pulmonary Arterial Hypertension
(2018) Joshi AA, Davey RA, Rao Y, Shen K, Benza R, Raina A Pulmonary Circulation
Complexity of Macrophage Migration Inhibitory Factor (MIF) and Other Angiogenic Biomarkers Profiling in Pulmonary Arterial Hypertension.
(2017) Marshall JD, Sauler M, Tonelli A, Rao Y, Bucala R, Lee P, Fares W Pulm Circ.
Circulating Biomarkers and Outcome from a Randomised Phase Ii Trial of Sunitinib Vs Everolimus for Patients with Metastatic Renal Cell Carcinoma
(2016) Voss MH, Chen D, Marker M, Hakimi AA, Lee C-H, Hsieh JJ, Knox JJ, Voi M, Motzer RJ British Journal of Cancer