Vitamin D-Binding Protein (VDBP)

Vitamin D-binding protein (VDBP) is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, urine, and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. VDBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. Over 80 variants of human VDBP have been identified. It was initially characterized as group-specific component or Gc-globulin and its identity as the plasma vitamin D binding protein was discovered in 1975. Originating in the liver, it has a strong homology with serum albumin and a-fetoprotein. Although many thousands of sera have been tested, deletion or gross alteration of the VDBP gene has not been detected; lending support to the notion that such mutations might be lethal.

Swiss-Prot Accession Number: P02774


 
 
Publications
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Synergistic Cytokine Effects as Apremilast Response Predictors in Patients With Psoriasis (2018) Garcet S, Nograles K, Correa da Rosa J, Schafer PH, Krueger JG Journal of Allergy and Clinical Immunology
Inflammatory proteins in nasal lavage of workers exposed to occupational agents. (2017) Castano R, Yucesoy B, Johnson VJ, Castellanos L, Cartier A Clin Exp Allergy
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports
Vitamin D Binding Protein as a Serum Biomarker of Alzheimer's Disease. (2014) Bishnoi RJ, Palmer RF, Royall DR. Journal of Alzheimer's Disease 2014 Jul 30. [Epub ahead of print]
Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis (2011) Guglielmelli P, Barosi G, Rambaldi A, Marchioli R, Masciulli A, Tozzi L, Biamonte F, Bartalucci N, Gattoni E, Lupo ML, Finazzi G, Pancrazzi A, Antonioli E, Susini MC, Pieri L, Malevolti E, Usala E, Occhini U, Grossi A, Caglio S, Paratore S, Bosi A, Barbui T, Vannucchi AM Blood. 2011 Jul 1. [Epub ahead of print]
The multiplex bead array approach to identifying serum biomarkers associated with breast cancer (2009) Kim BK, Lee JW, Park PJ, Shin YS, Lee WY, Lee KA, Ye S, Hyun H, Kang KN, Yeo D, Kim Y, Ohn SY, Noh DY, Kim CW Breast Cancer Res. 11: R22.