Serum Amyloid A Protein (SAA)
Serum Amyloid A (SAA) is the circulating precursor of amyloid A protein and has a number of immunomodulatory roles. SAA is an acute phase reactant and has been found to be elevated in many inflammatory states. SAA rises earlier and more sharply than CRP. The liver is the primary site of synthesis of SAA though extra-hepatic production has been demonstrated in macrophages, endothelial cells, epithelial cells, artherosclerotic lesions, tumors and synovial tissue.
Swiss-Prot Accession Number: P0DJI8
Publications Proteomics in Chronic Arthritis - Will We Finally Have Useful Biomarkers?
(2018) Kessel C, McArdle A, Verweyen E, Weinhage T, Wittkowski H, Pennington SR, Foell D Current Rheumatology Reports
Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges
(2015) O'Bryant SE, Listac S, Rissman RA, Edwards M, Zhang F, Hall J, Zetterberg H, Lovestone S, Gupta V, Graff-Radford N, Martins R, Jeromin A, Waring S, Oh E, King M, Baker L, Hampel H Alzheimers Dement (2015) 1-8
Plasma biomarkers in carbon monoxide poisoning.
(2010) Thom SR, Bhopale VM, Milovanova TM, Hardy KR, Logue CJ, Lambert DS, Troxel AB, Ballard K, Eisinger D Clin Toxicol (Phila) 48: 47-56.