Vitamin K-Dependent Protein S (VKDPS)

Vitamin K-Dependent Protein S (VKDPS), also known as PROS1 or Vitamin K dependent glycoprotein, serves as an anticoagulant plasma protein and is a co-factor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulates fibrinolysis. It also binds to negatively charged phospholipids which are displayed by apoptotic cells. VKDPS therefore acts as a bridge between macrophages and apoptotic cells reducing the inflammatory effects of apoptosis. Deficiency of VKDP is a vascular thrombosis risk factor.

Swiss-Prot Accession Number: P07225

Myriad RBM Publications Publications
Metabolomic analyses reveal lipid abnormalities and hepatic dysfunction in non-human primate model for Yersinia pestis (2019) Gautam A, Muhie S, Cakraborty N, Hoke A, Donohue D, Miller SA, Hammamieh R, Jett M Metabolomics
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports
Multiplex immunoassay analysis of plasma shows prominent upregulation of growth factor activity pathways linked to GSK3ß signaling in bipolar patients (2013) Haenisch F, Alsaif M, Guest PC, Rahmoune H, Dickerson F, Yolken R, Bahn S Journal of Affective Disorders