Granulins are a family of secreted, glycosylated peptides that are cleaved from the 88 kDa precursor protein, progranulin. Both the peptides and intact progranulin protein regulate cell growth. Granulin family members are important in normal development, wound healing and tumorigenesis. Mutations in the GRN gene have been implicated in up to 25% of frontotemporal lobar degeneration, a common cause of dementia. Progranulin has also been shown to be a new ligand of TNF receptors and a potential marker of chronic inflammation.
Swiss-Prot Accession Number: P28799