Monocyte Chemotactic Protein 4 (MCP-4)
Monocyte Chemotactic Protein 4 (MCP-4; CCL13) is a chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. MCP-4 is widely expressed, found in small intestine, thymus, colon, lung, trachea, stomach, and lymph node. Low levels are seen in the pulmonary artery smooth muscle cells. MCP-4 is induced by IL-1 and TNF alpha.
Swiss-Prot Accession Number: Q99616
Publications Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults.
(2019) Diniz BS, Reynolds Iii CF, Sibille E, Bot M, Penninx BWJH Translational Psychiatry
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment
(2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Serum thyroid-stimulating hormone and interleukin-8 levels in boys with autism spectrum disorder
(2017) Singh S, Yazdani U, Gadad B, Zaman S, Hynan LS, Roatch N, Schutte C, Marti CN, Hewitson L and German DC J. Neuroinflammation
A Sputum Proteomic Signature That Associates with Increased Il-1? Levels and Bacterial Exacerbations of COPD
(2016) Damera G, Pham T-H, Zhang J, Ward CK, Newbold P, Ranade K, Sethi S Lung
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests
(2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports
Plasma proteomics in CML patients before and after initiation of tyrosine kinase inhibitor therapy reveals induced Th1 immunity and loss of angiogenic stimuli.
(2016) Söderlund S, Christiansson L, Persson I, Hjorth-Hansen H, Richter J, Simonsson B, Mustjoki S, Olsson-Strömberg U, Loskog A. Leuk Res