Lymphotactin is a small chemokine that has chemotactic for lymphocytes but not for monocytes or neutrophils, a characteristic that makes it unique among chemokines. Lymphotactin is produced by NK cells and attracts both NK and T-cells in vivo, but it does not affect the adhesiveness of NK cells to vascular endothelium. Like some other chemokines, it possesses suppressive activity against immature subsets of myeloid progenitors stimulated to proliferate by multiple growth factors.
Swiss-Prot Accession Number: P47992
Publications Serum Apolipoprotein E and Other Inflammatory Markers Can Identify Non-Responding Patients to a Dendritic Cell Vaccine
(2018) Leeman H, Kaminska E, Green D, Bodman-Smith M, Gravett A, Bodman-Smith K, Copier J, Coulton G, Fusi A, Dalgleish AG Translational Oncology
A Canonical Transforming Growth Factor Beta-Dependent Signaling Pathway is Present in Peripheral Blood Cells of Cancer Patients with Skeletal Metastasis
(2013) Kadam S, Cleverly AL, Farmen M, Grondin J, Cox YI, Lahn M J Mol Biomark Diagn 2013, 4:3
Peripheral profiling analysis for bipolar disorder reveals markers associated with reduced cell survival
(2011) Herberth M, Koethe D, Levin Y, Schwarz E, Krzyszton ND, Schoeffmann S, Ruh H, Rahmoune H, Kranaster L, Schoenborn T, Leweke MF, Guest PC, Bahn S Proteomics 11: 94-105.
Comparative efficacy and safety of aliskiren and irbesartan in patients with hypertension and metabolic syndrome.
(2010) Krone W, Hanefeld M, Meyer HF, Jung T, Bartlett M, Yeh CM, Rajman I, Prescott MF, Dole WP J Hum Hypertens [Epub ahead of print]