Apolipoprotein(a) (Lp(a))

Apolipoprotein(a) (Lp(a)) also known as lipoprotein(a), is bound to both HDL and LDL. Lp(a) interferes with plasminogen, the clot dissolving enzyme, which binds to the arterial endothelial lining. This in turn contributes to blood clot formation, and over a prolonged period of time, would lead to significant damage to the coronary arteries. Unlike Apo A-I or Apo B, whose levels vary as a result of diet, exercise, etc., levels of Lp(a) are predominantly a genetic trait that remain more or less constant after puberty. Levels greater than 30mg/dl have been demonstrated to independently increase the risk of coronary heart disease by six fold.

Swiss-Prot Accession Number: P08519


 
 
Publications
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Towards a Blood-Based Diagnostic Panel for Bipolar Disorder (2016) Haenisch F, Cooper JD, Reif A, Kittel-Schneider S, Steiner J, Leweke FM, Rothermundt M, Van Beveren NJM, Crespo-Facorro B, Niebuhr DW, Cowan DN, Weber NS, Yolken RH, Penninx BWJH, Bahn S Brain, Behavior, and Immunity
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports
Early Role of Vascular Dysregulation on Late-Onset Alzheimer's Disease Based on Multifactorial Data-Driven Analysis (2016) Iturria-Medina Y, Sotero RC, Toussaint PJ, Mateos-Perez JM, Evans AC, The Alzheimer's Disease Neuroimaging Initiative Nature Communications
Apolipoprotein H Expression Is Associated with Il28b Genotype and Viral Clearance in Hepatitis C Virus Infection (2014) Laird ME, Mohsen A, Duffy D, Mamdouh R, Lefouler L, Casrouge A, El-Daly M, Rafik M, Abdel-Hamid M, Soulier A, Pawlotsky J-M, Hézode C, Rosa I, Renard P, Mohamed MK, Bonnard P, Izopet J, Mallet V, Pol S, Albert ML, Fontanet A Journal of Hepatology
Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: A randomized clinical trial (2012) Chiva-Blanch G, Urpi-Sarda M, Ros E, Valderas-Martinez P, Casas R, Arranz S, Guill?n M, Lamuela-Ravent?s RM, Llorach R, Andres-Lacueva C, Estruch R Clinical Nutrition (online September 3)
Plasma Protein Profiling Reveals Protein Clusters Related to BMI and Insulin Levels in Middle-Aged Overweight Subjects (2010) van Dijk SJ, Feskens EJM, Heidema AG, Bos MB, van de Rest O, Geleijnse JM, de Groot LCPGM, Muller M, Afman LA PLoS ONE 12: e14422.
Bead-based Multiplexed Immunoassays to Identify New Biomarkers in Maternal Serum to Improve First Trimester Down Syndrome Screening. (2009) Koster MP, Pennings JL, Imholz S, Rodenburg W, Visser GH, de Vries A, Schielen PC Prenat Diagn 29: 857-862.