Interleukin-6 (IL-6)

Interleukin-6 (IL-6) is a cytokine released by leukocytes in response to a number of inciting stimuli. In addition to its role as an acute phase reactant and endogenous pyrogen, IL-6 is also involved in B-cell differentiation into plasma cells. IL- 6 is usually not detected in normal serum, plasma, CSF, or joint fluid. Elevated levels are observed in a variety of inflammatory processes, including infections (endotoxemia) and collagen vascular diseases. IL-6 is also elevated in alcoholic cirrhosis and chronic renal failure.

Swiss-Prot Accession Number: P05231


Publications
A Multi-site In-depth Evaluation of the Qunaterix Simoa from a User's Perspective (2018) Chunyk A, Joyce A, Fischer S, Dysinger M, Mikulskis A, Jeromin A, Lawrence-Henderson R, Baker D, Yeung D The AAPS Journal 2018
Embelin and its derivatives unravel the signaling, proin?ammatoryand antiatherogenic properties of GPR84 receptor (2018) Gaidarov I, Anthony T, Gatlin J, Chen X, Mills D, Solomon M, Han S, Semple G, Unett DJ Pharmacological Research
Phase Ib Study of Glasdegib, A Hedgehog Pathway Inhibitor, in (2018) Savona M, Pollyea D, Stock W, Oehler V, Schroeder MA, Lancet J, McCloskey J, Kantarigian H, Ma WW, Shaik MN, Laird AD, Zeremski M, O'Connell A, Chan G, Cortes JE Clinical Cancer Research
Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury (2018) Proudfood A, Bayliffe A, O'Kane C, Wright T, Serone A, Bareille P, Brown V, Hamid U, Chen Y, Wilson R, Cordy J, Morley P, de Wildt Ruud, Elborn S, Hind M, Chilvres E, Griffiths M, Summers C, McAuley D Thorax
Key Proteins Involed in Spheroid Formation and Angiogenesis in Endothelial Cells After Long-Term Exposure to Simulated Microgravity (2018) Dittrich A, Grimm D, Sahana J, Bauer J, Kruger M, Infanger M, Magnusson N Cellular Physiology and Biochemistry 2018
Evaluation of plasma biomarkers of inflammation in patients with maple syrup urine disease (2018) Scaini G, Tonon T, Moura de Souza CF, Schuck PF, Ferreira GC, Quevedo J, Seda Neto J, Amorim T, Camelo Jr JS, Vitoria Barban Margutti A, Hencke Tresbach R, Sperb-Ludwig F, Boy R, V. de Medeiros PF, Schwards IVD, Luiz Streck E Journal of Inherited Metabolic Disease
Association between IL-6 production in synovial explants from rheumatoid arthritis patients and clinical and imaging response to biologic treatment: A pilot study (2018) Andersen M, Boesen M, Ellegaard K, Soderstrom K, Soe NH, Spee P, Morch UGW, Torp-Pedersen S, Bartels EM, Danneskiold-Samsoe B, Karlsson L, Bliddal H Plos One
IL-17 blockade with secukinumab in peripheral spondyloarthritis impacts synovial immunopathology without compromising systemic immune responses (2018) van Mens LJJ, van de Sande MGH, Menegatti S, Chen S, Blijdorp ICP, de Jong HM, Fluri IA, Latuhihin TE, van Kuijk AWR, Rogge L, Yeremenko NG, Baeten DLP Arthritis Rheumatol
Synergistic Cytokine Effects as Apremilast Response Predictors in Patients With Psoriasis (2018) Garcet S, Nograles K, Correa da Rosa J, Schafer PH, Krueger JG Journal of Allergy and Clinical Immunology
Cereblon modulator iberdomide induces degradation of the transcription factor Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus (2018) Schafer PH, Ye Y, Wu L, Kosek J, Ringheim G, Yang Z, Liu L, Thomas M, Palmisano M, Chopra R Ann Rheum Dis
Association between Cytokines and Functional, Hemodynamic Parameters, and Clinical Outcomes in Pulmonary Arterial Hypertension (2018) Joshi AA, Davey RA, Rao Y, Shen K, Benza R, Raina A Pulmonary Circulation
Proteomics in Chronic Arthritis - Will We Finally Have Useful Biomarkers? (2018) Kessel C, McArdle A, Verweyen E, Weinhage T, Wittkowski H, Pennington SR, Foell D Current Rheumatology Reports
Testing a multivariate proteomic panel for TBI biomarker discovery: A track-TBI pilot study (2018) Huie JR, Diaz-Arrastia R, Yue JK, Sorani M, Puccio A, Okonkwo DO, Manley GT, Ferguson AR Journal of Neurotrauma
Altered regulation of the T-cell system in patients with CRPS (2018) Heyn J, Azad SC, Luchting B Inflammation Research
Associations of 26 Circulating Inflammatory and Renal Biomarkers with Near-Infrared Spectroscopy and Long-term Cardiovascular Outcome in Patients Undergoing Coronary Angiography (ATHEROREMO-NIRS Substudy) (2018) Anroedh SS, Akkerhuis KM, Oemrawsingh RM, Garcia-Garcia HM, Brankovic M, Regar E, van Geuns RJ, Serruys PW, Daemen J, Van Mieghem NM, Boersma E, Kardys I Current Atherosclerosis Reports
Protein Biomarker Druggability Profiling (2017) Mani S, Cannon D, Ohls R, Oprea T, Mathias S, Ballard K, Ursu O, Bologa C J Biomed Inform
Soluble intercellular adhesion molecule-1: a potential biomarker for pain intensity in chronic pain patients. (2017) Luchting B, Hinske LC, Rachinger-Adam B, Celi LA, Kreth S, Azad SC Biomark Med
Effects of Traumeel (Tr14) on recovery and inflammatory immune response after repeated bouts of exercise: a double-blind RCT. (2017) Muders K, Pilat C, Deuster V, Frech T, Krüger K, Pons-Kuhnemann J, Mooren FC Eur J Appl Physiol.
Immunodepression after CPB: Cytokine dynamics and clinics after pediatric cardiac surgery – A prospective trial (2017) Justus G, Walker C, Rosenthal LM, Berger F, Miera O, Schmitt KR Cytokine
Complexity of Macrophage Migration Inhibitory Factor (MIF) and Other Angiogenic Biomarkers Profiling in Pulmonary Arterial Hypertension. (2017) Marshall JD, Sauler M, Tonelli A, Rao Y, Bucala R, Lee P, Fares W Pulm Circ.
Peripheral biomarkers of major depression and antidepressant treatment response: Current knowledge and future outlooks (2017) Gadad BS, Jha MK, Czysz A, Furman JL, Mayes TL, Emslie MP, Trivedi MH J Affect Disord
Cytokine Release and Focal Adhesion Proteins in Normal Thyroid Cells Cultured on the Random Positioning Machine. (2017) Warnke E, Pietsch J, Kopp S, Bauer J, Sahana J, Wehland M, Krüger M, Hemmersbach R, Infanger M, Lützenberg R, Grimm D Cell Physiol Biochem.
The role of anxious distress in immune dysregulation in patients with major depressive disorder. (2017) Gaspersz R, Lamers F, Wittenberg G, Beekman ATF, van Hemert AM, Schoevers RA, Penninx BWJH Transl Psychiatry
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges. (2017) Piasecka B, Duffy D, Urrutia A, Quach H, Patin E, Posseme C, Bergstedt J, Charbit B, Rouilly V, MacPherson CR, Hasan M, Albaud B, Gentien D, Fellay J, Albert ML, Quintana-Murci L, Milieu Intérieur Consortium Proc Natl Acad Sci U S A
Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity (2016) Dietsch GN, Lu H, Yang Y, Morishima C, Chow LQ, Disis ML, Hershberg RM PLoS ONE
Noninvasive Transcutaneous Vagus Nerve Stimulation Decreases Whole Blood Culture-Derived Cytokines and Chemokines: A Randomized, Blinded, Healthy Control Pilot Trial (2016) Lerman I, Hauger R, Sorkin L, Proudfoot J, Davis B, Huang A, Lam K, Simon B, Baker DG Neuromodulation: Technology at the Neural Interface
A multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of treatment with sirukumab (CNTO 136) in patients with active lupus nephritis (2016) Rovin B, van Vollenhoven R, Aranow C, Wagner C, Gordon R, Zhuang Y, Belkowski S, Hsu B Arthritis & Rheumatology
Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time (2016) Schild M, Eichner G, Beiter T, Zuegel M, Niess AM, Steinacker JM, Mooren FC Mediators of Inflammation
Assessment of Urine Proteomics in Type 1 Primary Hyperoxaluria*American Journal of Nephrology (2016) Brooks ER, Hoppe B, Milliner DS, Salido E, Rim J, Krevitt LM, Olson JB, Price HE, Vural G, Langman CB American Journal of Nephrology
Inflammatory Profile in Lrrk2-Associated Prodromal and Clinical Pd (2016) Brockmann K, Apel A, Schulte C, Schneiderhan-Marra N, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol J-C, Cormier F, Knorpp T, Joos TO, Gasser T, Schüle B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Marras C, Berg D, Maetzler W Journal of Neuroinflammation
Circulating Biomarkers and Outcome from a Randomised Phase Ii Trial of Sunitinib Vs Everolimus for Patients with Metastatic Renal Cell Carcinoma (2016) Voss MH, Chen D, Marker M, Hakimi AA, Lee C-H, Hsieh JJ, Knox JJ, Voi M, Motzer RJ British Journal of Cancer
Cytokine Production Capacity in Depression and Anxiety (2016) Vogelzangs N, De Jonge P, Smit JH, Bahn S, Penninx BW Translational Psychiatry
Primary Analysis Of A Phase II Open-Label Trial Of INCB039110, A Selective JAK1 Inhibitor, In Patients With Myelofibrosis (2016) Mascarenhas JO, Talpaz M, Gupta V, Foltz LM, Savona MR, Paquette R, Turner AR, Coughlin P, Winton E, Burn TC, O'Neill P, Clark J, Hunter D10, Assad A, Hoffman R, Verstovsek S Haematologica
Biological stress systems, adverse life events and the improvement of chronic multi-site musculoskeletal pain across a 6-year follow-up. (2016) Generaal E, Vogelzangs N, Macfarlane GJ, Geenen R, Smit JH, de Geus EJ, Dekker J, Penninx BW. J Pain
Exercise-induced cytokine changes in antigen stimulated whole-blood cultures compared to serum (2016) Pilat C, Krüger K, Frech T, Mooren FC J Immunol Methods.
Serum biomarkers and changes in clinical/MRI evidence of golimumab-treated patients with ankylosing spondylitis: results of the randomized, placebo-controlled GO-RAISE study (2016) Inman RD, Baraliakos X, Hermann KA, Braun J, Deodhar A, Heijde D, Xu S, and Hsu B Arthritis Res Ther.
Characterizing the Inflammatory Response in Esophageal Mucosal Biopsies in Children with Eosinophilic Esophagitis (2016) Sayej WN, Menoret A, Maharjan AS, Fernandez M, Wang Z, Balarezo F, Hyams JS, Sylvester FA, Vella AT Clinical & Translational Immunology
Protein biomarkers for the prediction of cardiovascular disease in type 2 diabetes. (2015) Looker HC, Colombo M, Agakov F, Zeller T, Groop L, Thorand B, Palmer CN, Hamsten A, de Faire U, Nogoceke E, Livingstone SJ, Salomaa V, Leander K, Barbarini N, Bellazzi R, van Zuydam N, McKeigue PM, Colhoun HM; on behalf of the SUMMIT Investigators. Diabetologia. 2015 Mar 5. [Epub ahead of print]
Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans (2015) Saykin A, Shen L, Xiohui Y, Kim S, Kwangsik N, Risacher SL, Ramanan VK, Foroud T, Faber KM, Sarwar N, Minsie L, Xiaolan H, Soares HD, Potkin S, Thompson PM, Kauwe JSK, Kaddurah-Daouk R, Green RC, Toga AW, Weiner MW Alzheimer's & Dementia
Late Stage Cancer Patients Remain Highly Responsive to Immune Activation by the Selective TLR8 Agonist Motolimod (VTX-2337) (2015) Dietsch GN, Randall TD, Gottardo R, Northfelt DW, Ramanathan RK, Cohen PA, Manjarrez KL, Newkirk M, Bryan JK, Hershberg RM Clinical Cancer Research
THU0223 Serum Biomarkers Associated with Changes in Asdas and MRI Following Treatment of Ankylosing Spondylitis with Golimumab (2015) Inman RD, Baraliakos X, Hermann KG, Braun J, Deodhar A, van der Heijde DF, Xu S, Hsu B Ann Rheum Dis
Common Effects on Cancer Cells Exerted by a Random Positioning Machine and a 2D Clinostat (2015) Svejgaard B, Wehland M, Ma X, Kopp S, Sahana J, Warnke E, Aleshcheva G, Hemmersbach R, Hauslage J, Grosse J, Bauer J, Corydon TJ, Islam T, Infanger M, Grimm D PLoS One
Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges (2015) O'Bryant SE, Listac S, Rissman RA, Edwards M, Zhang F, Hall J, Zetterberg H, Lovestone S, Gupta V, Graff-Radford N, Martins R, Jeromin A, Waring S, Oh E, King M, Baker L, Hampel H Alzheimers Dement (2015) 1-8
Synovial explant inflammatory mediator production corresponds to rheumatoid arthritis imaging hallmarks: a cross sectional study (2014) Andersen, M., Boesen, M., Ellegaard, K., Christensen, R., Söderström, K., Søe, N., & Bliddal, H Arthritis Research & Therapy, 16(3), R107
A prospective assessment of the effect of aminophylline therapy on urine output and inflammation in critically ill children (2014) Tamburro RF, Thomas NJ, Ceneviva GD, Dettorre MD, Brummel GL, Lucking SE Front. Pediatr. 2:59
Exploring effects of a natural combination medicine on exercise-induced inflammatory immune response: A double-blind RCT (2014) Pilat C, Frech T, Wagner A, Krüger K, Hillebrecht A, Pons-Kühnemann J, Scheibelhut C, Bödeker RH, Mooren FC Scand J Med Sci Sports. 2014 Jun 12
Effects of alcohol and polyphenols from beer on atherosclerotic biomarkers in high cardiovascular risk men: a randomized feeding trial (2014) Chiva-Blancha G, Magraner E, Condines X, Valderas-Martínez P, Roth I, Arranz S, Casa R, Navarro M, Hervas A, Sisó A, Martínez-Huélamo M, Vallverdú-Queralt A, Quifer-Rada P, Lamuela-Raventos R-M, Estruch R Elsevier - Nutrition, Metabolism and Cardiovascular Diseases 2014 Aug 2; doi: 10.1016/j.numecd.2014.07.008
An integrated omics analysis: impact of microgravity on host response to lipopolysaccharide in vitro (2014) Chakraborty N, Gautam A, Muhie S, Miller SA, Jett M, Hammamieh R. BMC Genomics 2014 Aug 7;15(1):659. [Epub ahead of print]
Serum protein profiling reveals baseline and pharmacodynamic biomarker signatures associated with clinical outcome in mCRC patients treated with chemotherapy ± cediranib. (2014) Pommier AJ, Shaw R, Spencer SK, Morgan SR, Hoff PM, Robertson JD, Barry ST, Jürgensmeier JM. British Journal of Cancer 2014 Aug 14. doi: 10.1038/bjc.2014.436. [Epub ahead of print]
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. (2014) Herbst RS, Soria JC, Kowanetz M, Fine GD, Hamid O, Gordon MS, Sosman JA, McDermott DF, Powderly JD, Gettinger SN, Kohrt HE, Horn L, Lawrence DP, Rost S, Leabman M, Xiao Y, Mokatrin A, Koeppen H, Hegde PS, Mellman I, Chen DS, Hodi FS. Nature. 2014 Nov 26;515(7528):563-7. doi: 10.1038/nature14011.
Distinctive Colonic Mucosal Cytokine Signature in New-Onset, Untreated Pediatric Crohn Disease (2014) Sylvester FA, Draghi A, Menoret A, Fernandez ML, Wang Z, Vella AT Journal of Pediatric Gastroenterology and Nutrition
Circulating Cytokines in Relation to the Extent and Composition of Coronary Atherosclerosis: Results from the Atheroremo-Ivus Study (2014) Battes LC, Cheng JM, Oemrawsingh RM, Boersma E, Garcia-Garcia HM, De Boer SPM, Buljubasic N, Mieghem NaV, Regar E, Geuns R-JV, Serruys PW, Akkerhuis KM, Kardys I Atherosclerosis
The effects of vitamin A on cells of innate immunity in vitro (2013) Wojtal K, Wolfram L, Frey-Wagner I, Lang S, Scharl M, Vavricka SR, Rogler G Toxicology in Vitro,
Intracellular Aggregation of Multimodal Silica Nanoparticles for (2013) Jokerst JV, Khademi C, Gambhir SS Sci Transl Med. 2013 Mar 20;5(177):177ra35
Impact of Sunitinib on Human Thyroid Cancer Cells (2013) Grosse J, Warnke E, Pohl F, Magnusson NE, Wehland M, Infanger M, Eilles C, Grimm D Cell Physiol Biochem. 2013 Jul 12;32(1):154-170
IL-6 pathway-driven investigation of response to IL-6 receptor inhibition in rheumatoid arthritis (2013) Wang J, Platt A, Upmanyu R, Germer S, Lei G, Rabe C, Benayed R, Kenwright A, Hemmings A, Martin M, Harari O BMJ Open. 2013 Aug 19;3(8):e003199
Biomarker identification in serum samples from patients with recurrent cervical cancer treated with ADXS11-001 immunotherapy (2013) Molli P, Malinina I, Wallecha A Journal for ImmunoTherapy of Cancer 2013, 1(Suppl 1):P61
Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space (2013) Ma X, Pietsch J, Wehland M, Schulz H, Saar K, Hübner N, Bauer J, Braun M, Schwarzwälder A, Segerer J, Birlem M, Horn A, Hemmersbach R, Waßer K, Grosse J, Infanger M, Grimm D FASEB J. 2013 Nov 6. [Epub ahead of print]
Identification of a molecular profile associated with immune status in first onset schizophrenia patients (2013) Herberth M, Rahmoune H, Schwarz E, Koethe D, Harris LW, Kranaster L, Witt SH, Spain M, Barnes A, Schmolz M, Leweke MF, Guest PC, Bahn S Clin Schizophr Relat Psychoses
Plasma metabolomics and proteomics profiling after a postprandial challenge reveal subtle diet effects on human metabolic status (2012) Pellis L, van Erk MJ, van Ommen B, Bakker GCM, Hendriks HFJ, Cnubben NHP, Kleemann R, van Someren EP, Bobeldijk I, Rubingh CM, Wopereis S Metabolomics
STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma (2012) Looyenga BD, Hutchings D, Cherni I, Kingsley C, Weiss GJ, MacKeigan JP PLoS ONE 7(2): e30820
A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis (2012) Verstovsek S, Mesa RA, Gotlib J, Levy RS, Gupta V, DiPersio JF, Catalano JV, Deininger M, Miller C, Silver RT, Talpaz M, Winton EF, Harvey JH Jr, Arcasoy MO, Hexner E, Lyons RM, Paquette R, Raza A, Vaddi K, Erickson-Viitanen S, Koumenis IL, Sun W, Sandor V, Kantarjian HM N Engl J Med. 2012 Mar;366(9):799-807
Multivariate Protein Signatures of Pre-Clinical Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Plasma Proteome Dataset (2012) Johnstone D, Milward EA, Berretta R, Moscato P PLoS One. 2012;7(4):e34341
Increased serum ß2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus (2012) Hermansen ML, Hummelshøj L, Lundsgaard D, Hornum L, Keller P, Fleckner J, Fox B, Poulsen LK, Jacobsen S Lupus. 2012 May 10. [Epub ahead of print]
Highly aggregated antibody therapeutics can enhance the in vitro innate and late-stage T-cell immune responses (2012) Joubert MK, Hokom M, Eakin C, Zhou L, Deshpande M, Baker MP, Goletz TJ, Kerwin BA, Chirmule N, Narhi LO, Jawa V J Biol Chem. 2012 Jul 20;287(30):25266-79
Photoacoustic Imaging of Mesenchymal Stem Cells in Living Mice via Silica-Coated Gold Nanorods (2012) Jokerst JV, Thangaraj M, Kempen P, Sinclair R, Gambhir SS ACS Nano. 2012 Jun 10. [Epub ahead of print]
Blood profiling of proteins and steroids during weight maintenance with manipulation of dietary protein level and glycaemic index (2012) Wang P, Holst C, Astrup A, Bouwman FG, van Otterdijk S, Wodzig WK, Andersen MR, van Baak MA, Rasmussen LG, Martinez JA, Jebb SA, Pfeiffer AF, Kafatos A, Handjieva-Darlenska T, Hlavaty P, Saris WH, Mariman EC Br J Nutr. 2012 Jan;107(1):106-19
Intraindividual long term stability and response corridors of cytokines in healthy volunteers detected by a standardized whole-blood culture system for bed-side application (2012) Mueller SC, März R, Schmolz M, Drewelow B BMC Med Res Methodol. 2012 Aug 1;12(1):112
Characterization of immunologically active drugs in a novel organotypic co-culture model of the human gut and whole blood (2012) Schmohl M, Schneiderhan-Marra N, Baur N, Hefner K, Blum M, Stein GM, Joos TO, Schmolz M Int Immunopharmacol. 2012 Dec;14(4):722-8
High tumor levels of IL6 and IL8 abrogate preclinical efficacy of the gamma-secretase inhibitor, RO4929097 (2011) He W, Luistro L, Carvajal D, Smith M, Nevins T, Yin X, Cai J, Higgins B, Kolinsky K, Rizzo C, Packman K, Heimbrook D, Boylan JF Molecular Oncology [Epub ahead of print]
Molecular Markers for Diagnosis of Periprosthetic Joint Infection (2011) Jacovides CL, Parvizi J, Adeli B, Jung KA J Arthroplasty. 2011 May 12. [Epub ahead of print]
Bone Marrow Derived Mesenchymal Stromal Cells are Attracted by Multiple Myeloma Cell-Produced Chemokine CCL25 and Favor Myeloma Cell Growth In Vitro and In Vivo (2011) Xu S, Menu E, De Becker A, Van Camp B, Vanderkerken K, Van Riet I Stem Cells. 2011 Nov 18. [Epub ahead of print]
Effects of Echinaforce® treatment on ex vivo-stimulated blood cells (2011) Ritchie MR, Gertsch J, Klein P, Schoop R Phytomedicine. 2011 Jul 15;18(10):826-31
Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis (2011) Guglielmelli P, Barosi G, Rambaldi A, Marchioli R, Masciulli A, Tozzi L, Biamonte F, Bartalucci N, Gattoni E, Lupo ML, Finazzi G, Pancrazzi A, Antonioli E, Susini MC, Pieri L, Malevolti E, Usala E, Occhini U, Grossi A, Caglio S, Paratore S, Bosi A, Barbui T, Vannucchi AM Blood. 2011 Jul 1. [Epub ahead of print]
Association of serum markers with improvement in clinical response measures after treatment with golimumab in patients with active rheumatoid arthritis despite receiving methotrexate: results from the GO-FORWARD study (2010) Visvanathan S, Rahman MU, Keystone E, Genovese M, Klareskog L, Hsia E, Mack M, Buchanan J, Elashoff M, Wagner C Arthritis Res Ther. 12:R211
Bevacizumab therapy normalizes the pathological intraocular environment beyond neutralizing VEGF (2010) Sharma RK, Rogojina AT, Chalam KV Mol Vi. 16: 2175-2184.
Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis (2010) Verstovsek S, Kantarjian H, Mesa RA, Pardanani AD, Cortes-Franco J, Thomas DA, Estrov Z, Fridman JS, Bradley EC, Erickson-Viitanen S, Vaddi K, Levy R, Tefferi A N Engl J Med. 363: 1117-27.
Limited Systemic Sclerosis Patients with Pulmonary Arterial Hypertension Show Biomarkers of Inflammation and Vascular Injury (2010) Pendergrass SA, Hayes E, Farina G, Lemaire R, Farber HW, Whitfield ML, Lafyatis R. PLoS ONE 5: e12106.
In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation (2010) Marballi K, Quinones MP, Jimenez F, Escamilla MA, Raventós H, Soto-Bernardini MC, Ahuja SS, Walss-Bass C J Mol Med. 88: 1133-41.
Plasma Protein Profiling Reveals Protein Clusters Related to BMI and Insulin Levels in Middle-Aged Overweight Subjects (2010) van Dijk SJ, Feskens EJM, Heidema AG, Bos MB, van de Rest O, Geleijnse JM, de Groot LCPGM, Muller M, Afman LA PLoS ONE 12: e14422.
Multi analyte profiling and variability of inflammatory markers in blood and induced sputum in patients with stable COPD (2010) Aaron SD, Vandemheen KL, Ramsay T, Zhang C, Avnur Z, Nikolcheva T, Quinn A Respir Res. 2010 Apr 22;11:41
Peripheral Blood Biomarkers Predict Disease Progression And Mortality In IPF (2010) Richards TJ, Lindell KO, Klesen M, Kaminski N, Zhang Y, Gibson KF Am J Respir Crit Care Me 181: A1120.
Plasma biomarkers in carbon monoxide poisoning. (2010) Thom SR, Bhopale VM, Milovanova TM, Hardy KR, Logue CJ, Lambert DS, Troxel AB, Ballard K, Eisinger D Clin Toxicol (Phila) 48: 47-56.
High content analysis of human fibroblast cell cultures after exposure to space radiation (2009) Dieriks B, De Vos W, Meesen G, Van Oostveldt K, De Meyer T, Ghardi M, Baatout S, Van Oostveldt P Radiat Res. 172: 423-36.
Molecular Analyte Profiling of the Early Events and Tissue Conditioning Following Intravesical Bacillus Calmette-Guerin Therapy in Patients With Superficial Bladder Cancer. (2009) Bisiaux A, Thiounn N, Timsit MO, Eladaoui A, Chang HH, Mapes J, Mogenet A, Bresson JL, Prié D, Béchet S, Baron C, Sadorge C, Thomas S, Albert EB, Albert PS, Albert ML J Urol 181: 1571-1580.
Development and Preliminary Evaluation of a Multivariate Index Assay for Ovarian Cancer. (2009) Amonkar SD, Bertenshaw GP, Chen TH, Bergstrom KJ, Zhao J, Seshaiah P, Yip P, Mansfield BC PLoS ONE 4: e4599.
Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma. (2008) Ding Y, Boguslawski EA, Berghuis BD, Young JJ, Zhang Z, Hardy K, Furge K, Kort E, Frankel AE, Hay RV, Resau JH, Duesbery NS Mol Cancer Ther 7: 648-658.
IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells. (2008) Smithgall MD, Comeau MR, Yoon BR, Kaufman D, Armitage R, Smith DE Int Immunol 20: 1019-1030.
Neighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells. (2007) Caers J, Deleu S, Belaid Z, De Raeve H, Van Valckenborgh E, De Bruyne E, Defresne MP, Van Riet I, Van Camp B, Vanderkerken K Leukemia 21: 1580-1584.
Effects of the incubation in vitro with sorbents on serum proteomic pattern and cytokine concentration in cancer patients during chemotherapy--preliminary results. (2006) Piccolomini F, LouWratten M, Sereni L, Balestreri E, Donadio E, Felicioli A, Felicioli R, Donadio C Biomed Pharmacother 60: 463-467.
Validation of a new highly standardised, lab-independent whole-blood leukocyte function assay for clinical trials (ILCS). (2004) Schmolz M, Hurst TL, Bailey DM, Powell JR, Forsey RJ, Thompson JM, Williams C, Pawelec G Exp Gerontol 39: 667-671.