T Lymphocyte-Secreted Protein I-309 (I-309)
T Lymphocyte-Secreted Protein I-309 (I-309; CCL1), also known as small inducible cytokine A1, is a small glycoprotein secreted by activated T cells that belongs to a family of inflammatory cytokines known as chemokines. It is chemotactic for monocytes but not for neutrophils. CCL1 attracts monocytes, NK cells, immature B cells, and dendritic cells by interacting with a cell surface chemokine receptor called CCR8.
Swiss-Prot Accession Number: P22362
Publications Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment
(2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment
(2010) Hu WT, Chen-Plotkin A, Arnold SE, Grossman M, Clark CM, Shaw LM, Pickering E, Kuhn M, Chen Y, McCluskey L, Elman L, Karlawish J, Hurtig HI, Siderowf A, Lee VM, Soares H, Trojanowski JQ Acta Neuropathol 119: 669-678.