Heparin-Binding EGF-Like Growth Factor (HB-EGF)

Heparin-binding EGF-like growth factor (HB-EGF) may play a role in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not for endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. HB-EGF was originally purified from U-937 lymphoma cell line. The differential activities of HB-EGF compared to EGF may be mediated by the heparin-binding properties of the former. Transcription of HB-EGF can be induced in vascular endothelial cells as well as aortic smooth muscle cells (SMC), suggesting that HB-EGF may play a role in atherosclerosis.

Swiss-Prot Accession Number: Q99075


Myriad RBM Publications Publications
Serum proteins mediate depression’s association with dementia (2017) Royall DR, Al-Rubaye S, Bishnoi R, Palmer RF Plos One
Assessing biological and technological variability in protein levels measured in pre-diagnostic plasma samples of women with breast cancer. (2017) Yeh CY, Adusumilli R, Kullolli M, Mallick P, John EM, Pitteri SJ Biomark Res.
Allogeneic mesenchymal stem cell infusion for the stabilization of focal segmental glomerulosclerosis (2013) Belingheri M, Lazzari L, Parazzi V, Groppali E, Biagi E, Gaipa G, Giordano R, Rastaldi MP, Croci D, Biondi A, Rebulla P, Edefonti A, Ghio L Biologicals. 2013 Oct 14. pii: S1045-1056(13)00111-5. doi: 10.1016/j.biologicals.2013.09.004
Identification of Subgroups of Schizophrenia Patients with Changes in Either Immune or Growth Factor and Hormonal Pathways (2013) Schwarz E, Van Beveren NJM, Ramsey J, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Guest PC, Bahn S Schizophrenia Bulletin
Multivariate Protein Signatures of Pre-Clinical Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Plasma Proteome Dataset (2012) Johnstone D, Milward EA, Berretta R, Moscato P PLoS One. 2012;7(4):e34341
Systemic Biomarkers of Neutrophilic Inflammation, Tissue Injury and Repair in COPD Patients with Differing Levels of Disease Severity (2012) Cockayne DA, Cheng DT, Waschki B, Sridhar S, Ravindran P, Hilton H, Kourteva G, Bitter H, Pillai SG, Visvanathan S, Müller KC, Holz O, Magnussen H, Watz H, Fine JS PLoS One. 2012;7(6):e38629