Clusterin (CLU)

Clusterin (CLU) is the most widely accepted name for a highly conserved protein that has been identified independently by many different laboratories. Other names for CLU include: SGP2, S35-S45, apolipoprotein J, SP-40, 40, ADHC-9, gp80, GPIII, and testosterone-repressed prostate message (TRPM-2). Clusterin has been associated with the clearance of cellular debris and apoptosis. Other functions include the control of complement-mediated cell lysis, shuttling of aberrant beta-amyloid across the blood-brain barrier and lipid scavenging. The measurement of urinary or serum clusterin may play a role in the early detection of renal injury. Increased urinary levels have been observed in rat models of tubular proteinuria but not glomerular proteinuria. Increased levels have also been seen in Alzheimer’s patients.

Swiss-Prot Accession Number: P10909


Publications
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Pharmacokinetics of Telavancin at Fixed Doses in Normal-Body-Weight and Obese (Classes I, II and III) Adult Subjexts (2018) Bunnell KL, Pai MP, Sikka M, Bleasdale S, Wenzler E, Danziger LH, Rodvold KA Antimicrobial Agents and Chemotherapy
Evaluation of Novel Biomarkers of Nephrotoxicity in Cynomolgus Monkeys Treated with Gentamicin (2016) Gautier J-C, Zhou X, Yang Y, Gury T, Qu Z, Palazzi X, Léonard J-F, Slaoui M, Veeranagouda Y, Guizon I, Boitier E, Filali-Ansary A, van den Berg BHJ, Poetz O, Joos T, Zhang T, Wang J, Detilleux P, Li B Toxicology and Applied Pharmacology
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports
A Potential Endophenotype for Alzheimer's Disease: Cerebrospinal Fluid Clusterin (2016) Deming Y, Xia J, Cai Y, Lord J, Holmans P, Bertelsen S, Holtzman D, Morris JC, Bales K, Pickering EH, Kauwe J, Goate A, Cruchaga C Neurobiology of Aging
Identification of Plexin A4 as a Novel Clusterin Receptor Links Two Alzheimer's Disease Risk Genes (2016) Kang SS, Kurti A, Wojtas A, Baker KE, Liu CC, Kanekiyo T, Deming Y, Cruchaga C, Estus S, Bu G, Fryer JD Human Molecular Genetics
Characterization of Renal Biomarkers for Use in Clinical Trials: Effect of Preanalytical Processing and Qualification Using Samples from Subjects with Diabetes (2015) Brott DA, Furlong ST, Adler SH, Hainer JW, Arani RB, Pinches M, Rossing P, Chaturvedi N Drug Design, Development and Therapy
Multiplex immunoassay analysis of plasma shows prominent upregulation of growth factor activity pathways linked to GSK3ß signaling in bipolar patients (2013) Haenisch F, Alsaif M, Guest PC, Rahmoune H, Dickerson F, Yolken R, Bahn S Journal of Affective Disorders
Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals (2012) Song F, Poljak A, Crawford J, Kochan NA, Wen W, Cameron B, Lux O, Brodaty H, Mather K, Smythe GA, Sachdev PS PLoS One. 2012;7(6):e34078
Assessment of Biomarkers of Drug-induced Kidney Injury in Cynomolgus Monkeys Treated with a Triple Re-uptake Inhibitor (2011) Guha M, Heier A, Price S, Bielenstein M, Caccese RG, Heathcote DI, Simpson TR, Stong DB, Bodes E Toxicol Sci. 2011 Jan 22. [Epub ahead of print]
Plasma clusterin and the risk of Alzheimer disease (2011) Schrijvers EM, Koudstaal PJ, Hofman A, Breteler MM JAMA. 305: 1322-6
A guidance for renal biomarker lead optimization and use in translational pharmacodynamics (2010) Ozer JS Drug Discov Today15: 142-7.