Agouti-Related Protein (AgRP)
Agouti-related Protein (AgRP) is a neuropeptide produced in the brain and a potent appetite stimulator. It is inhibited by the hormone leptin and functions as an antagonist for melanocortin receptors. AgRP is expressed primarily in the adrenal gland, subthalamic nucleus and hypothalamus, but is also found in lower levels in the testes, lung and kidney. Defects in AGRP may be a cause of autosomal dominant obesity.
Swiss-Prot Accession Number: O00253
Publications Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment
(2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
A Semi-Mechanism Approach Based on Mri and Proteomics for Prediction of Conversion from Mild Cognitive Impairment to Alzheimerâ€™s Disease
(2016) Liu H, Zhou X, Jiang H, He H, Liu X Scientific Reports
Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment
(2010) Hu WT, Chen-Plotkin A, Arnold SE, Grossman M, Clark CM, Shaw LM, Pickering E, Kuhn M, Chen Y, McCluskey L, Elman L, Karlawish J, Hurtig HI, Siderowf A, Lee VM, Soares H, Trojanowski JQ Acta Neuropathol 119: 669-678.
Novel CSF biomarkers for frontotemporal lobar degenerations
(2010) Hu WT, Chen-Plotkin A, Grossman M, Arnold SE, Clark CM, Shaw LM, McCluskey L, Elman L, Hurtig HI, Siderowf A, Lee VM, Soares H, Trojanowski JQ Neurology 75: 2079-86.