Recorded Webinar: Standardized Assays for Personalized Immune Response Monitoring

If you were unable to attend the webinar or would like to view the webinar again, a recorded version is now available for your convenience. This online seminar provides an overview of research published in Immunity that demonstrates progress in the standardization of assays for personalized immune response monitoring.

Biomarkers for a new cancer immunotherapy drug

This month’s paper features the results of a Phase I study on a new cancer immunotherapy drug. VTX-2337 is a toll-like receptor 8 agonist, activating a part of the innate immune system to stimulate a response that promotes anti-tumor activity. Here, biomarker data is shown that supports activation of the TLR8 pathway and the authors state that future research will use these targets to measure activity when the drug is combined with other agents to modulate TLR8. This research demonstrates an important role for biomarkers in the promising new field of cancer immunotherapy.

Inflammatory and metabolic biomarkers indicate colorectal cancer (CRC) risk

A study recently published in the European Journal of Epidemiology evaluated the correlation of colorectal cancer risk and biomarker patterns of inflammatory and metabolic pathways. The researchers concluded that several markers, including adiponectin, C-reactive protein (CRP), and leptin, are associated with CRC development.

The Importance of Sample Handling and Curation

Careful sample handling is critical to maintaining the long term value of legacy samples. Strict protocols and processes are essential to the curation of samples for future study.

A New Generation of Biomarkers for Detecting Early Signs of Kidney Damage

Nephrotoxicity is a major problem in the preclinical and clinical setting that results in the failure of candidate compounds throughout the drug-development cycle. An article in this month’s GEN outlines the development of a new generation of biomarkers for drug-induced toxicity that provides greater sensitivity and earlier detection than previous methods.

Biomarkers of Concussion May Speed Diagnosis

Traumatic brain injuries and concussions are rather common in contact sports, resulting in a variety of symptoms including dizziness, headaches, nausea, and sometimes loss of consciousness. The long-term effects of concussions are still being studied but researchers believe that cumulative blunt force trauma over a career may result in serious neurological conditions later in life. Objective biomarkers of concussion would allow doctors to detect minor brain injuries and treat athletes appropriately. New research published in JAMA Neurology has identified several proteins in the blood of professional hockey players that indicates damage to brain tissue.
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