Human Cytokine Testing on Cell Culture Supernatant for SPHEROIDS project

3D Growth of Endothelial Cells During ISS Space Mission – The SPHEROIDS Project

The April 2017 issue of Biomaterials reports on an automated cell culture unit that was developed for the SpaceX CRS-ISS space mission that resulted in three dimensional growth of human endothelial cells in microgravity.

A spaceflight to the International Space Station, carried out in April – May 2016, included a study to examine endothelial cell (EC) behavior in respect to cellular proliferation and apoptosis under spaceflight conditions to examine the gravity dependency of EC tube formation.

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Phase I Clinical Results from FR104, a mAb Specific to CD28

Researchers led by Bernard Vanove of OSE Immunotherapeutics report in the December 7, 2016 issue of the Journal of Immunology on the first-in-human study of FR1041. OSE and collaborators at the University of Nantes and Janssen conducted a detailed phase I evaluation of safety, pharmacokinetics, pharmacodynamics and potency of FR104 in healthy volunteers.

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GDF-15 as a Possible Biomarker for Use and Dosing of Metformin in Type II Diabetes

Novel nonglycemic biomarker for metformin

The Outcome Reduction with Initial Glargine Intervention (ORIGIN) trial delivers more insight on biomarkers that have potential to help treat patients with dysglycemia.1 Hertzel C. Gerstein and colleagues report Growth Differentiation Factor 15 as a novel biomarker for the use and dosing of metformin, in a study published in Diabetes Care last month.

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Induced immune responses in monkeys alter with movement in social status

Social status can be used as predictor of life expectancy and overall health.  It is easy to conclude that this is a result of better diet, healthcare, and lack of external risk factors but, as a team of researchers reported in the November 25th issue of the journal Science, movement in social status in rhesus macaques influenced changes in immune system phenotypes.

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